[NIH]      [NSF]

Stem Cell Research for Regenerative Medicine and Tissue Engineering

February 1–2, 2007
National Science Foundation
4201 Wilson Boulevard, Room 375
Arlington, Virginia 22230

Co-chairs: Molly Shoichet (University of Toronto) & Arnold Caplan (Case Western Reserve University)


The National Institutes of Health (NIH) and the National Science Foundation (NSF) sponsored this Workshop on Stem Cell Research in Regenerative Medicine and Tissue Engineering on February 1-2, 2007 at the National Science Foundation. The goals of the workshop were to bring together the thought leaders in these fields to access the state-of-the-art, to define the opportunities and challenges that are being faced, and to discern how the two communities in Stem Cells and Tissue Engineering can collaborate to accelerate and advance the scientific process with emphasis on clinical development. An important objective of this workshop was to bring together stem cell and tissue engineering/regenerative medicine researchers to help build better connections between these two communities. The results of the workshop may also be useful to the Multi-Agency Tissue Engineering Science (MATES) Interagency Working Group (IWG) in which NIH, NSF and other Federal agencies participate.


Thursday, February 1, 2007

7:30 Refreshments/Registration
8:10 Introductory Remarks: Fred Heineken, MATES IWG Chair
8:15 Welcome: Dr. Kathie Olsen, Deputy Director, National Science Foundation
8:25 Workshop Objectives: Fred Heineken
8:35 Organizer Philosophy: Molly Shoichet, University of Toronto, and Arnold I. Caplan, Case Western Reserve University
8:45 Overview - Stem Cells Case Study: "MSCs Structure Regenerative Microenvironments" [Abstract] - Arnold Caplan
9:30 Discussion/Question and Answer
9:45 Break
10:10 "Tissue Engineering Challenges" [Abstract] - Molly Shoichet
10:30 Discussion/Question and Answer
10:45 "The Challenge of Translation: From Bench to Bedside" [Abstract] - Scott P. Bruder, M.D., Ph.D., Worldwide Vice President, Johnson & Johnson Regenerative Therapeutics
11:15 Discussion/Question and Answer


(Chairs: Arnold Caplan and Molly Shoichet)
11:30 Heart
  1. Stem Cells: "Endogenous Cardiac Stem Cells" [Abstract] - Eduardo Marbán, Chief of Cardiology, Johns Hopkins Medicine; Professor of Medicine, Biomedical Engineering and Physiology, The Johns Hopkins University
  2. Tissue Engineering: "Tissue Engineering of a Cardiac Patch" [Abstract] - Gordana Vunjak-Novakovic, Professor of Biomedical Engineering, Columbia University
  3. Translation: "Critical Considerations in Vascular Devise-Based Delivery of Cell Therapies" [Abstract] - Maria Palasis, Ph.D.,  Director of Bioengineering, Boston Scientific Corporation
12:15 Discussion/Question and Answer
12:30 Lunch
1:30 Neural
  1. Stem Cells: "The Homeostatic Pressure Exerted by Stem Cells in Degenerative or Injured CNS Environments" [Abstract] - Evan Y. Snyder, M.D., Ph.D., Burnham Institute for Medical Research
  2. Tissue Engineering: "Engineering Approaches to Regenerating Damaged Neural Tissue" [Abstract] - Christine E. Schmidt, Associate Professor of Biomedical Engineering and Chemical Engineering, The University of Texas at Austin
  3. Translation: "Transplantation of Embryonic Stem Cell-Derived Progenitor Cells for CNS Repair" [Abstract] - Edward Wirth, III, Associate Medical Director, Geron Corporation
2:15 Discussion/Question and Answer
2:30 Break
3:00 Bone
  1. Stem Cells: “The Clinical Application of Human Connective Tissue Progenitor Biology to Bone Tissue Engineering” [Abstract] - George F. Muschler, M.D., Professor of Surgery and Molecular Medicine, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University; Vice Chairman, Department of Biomedical Engineering, Cleveland Clinic; Director, Orthopedic Research Center, Cleveland Clinic; and Director, Clinical Tissue Engineering Center
  2. Tissue Engineering: “Bone Tissue Engineering Requires Multiple Cell Lineages” [Abstract] - Jeremy Mao, Associate Professor of Dental Medicine and Biomedical Engineering, Columbia University
  3. Translation: "Tissue Repair Cells: Autologous Stem Cell Therapy for Bone and Tissue Regeneration" [Abstract]- Ronnda L. Bartel, Ph.D., Vice President, Research and Development, Aastrom
3:45 Discussion/Question and Answer
4:00 Cartilage
  1. Stem Cells: "Stem Cells and Regenerative Medicine for Osteoarthritis" [Abstract] - Farshid Guilak, Ph.D., Laszlo Ormandy Professor, Duke University Medical Center
  2. Tissue Engineering: "Cartilage Tissue Engineering and Joint Repair" [Abstract] - Rita Kandel, M.D., Professor, Department of Laboratory Medicine and Pathobiology, Mt. Sinai Hospital and University of Toronto
  3. Translation: “Hyaluronan Based Scaffolds in Tissue Engineering of Cartilage - A Review” [Abstract] - Alessandra Pavesio, Director of Research and Development, Fidia Advanced Biopolymers
4:45 Discussion/Question and Answer
5:00 Break
6:00 Cocktails (cash bar) at Vantage Point Restaurant, Holiday Inn Rosslyn at Key Bridge (top floor)
6:30 Dinner at Vantage Point Restaurant, Holiday Inn Rosslyn at Key Bridge (top floor)
7:30 Venture Funding: "Stem Cells: Yesterday, Today and Tomorrow"  - G. Steven Burrill, Burrill & Company

Friday, February 2, 2007

7:30 Refreshments
8:00 Tissue Engineering Case Study: "Using Stem Cells for New Frontiers" - Anthony Atala, Wake Forest University
8:45 Discussion/Question and Answer
9:00 Vascularization
  1. Stem Cells: "Stem/Progenitor Cells for Vascular Regeneration"  - Karen K. Hirschi, Associate Professor, Depts. of Pediatrics and of Molecular & Cellular Biology, and Deputy Director, Stem Cell and Regenerative Medicine Center, Baylor College of Medicine
  2. Tissue Engineering: "Materials for Angiogenesis on Demand" [Abstract] - David J. Mooney, Gordon McKay Professor of Bioengineering, Division of Engineering and Applied Sciences, Harvard University
  3. Translation: "Strategies for Vascularization and Controlling Remodeling" [Abstract] - Michael V. Sefton, University Professor, Institute of Biomaterials and Biomedical Engineering, University of Toronto
9:45 Discussion/Question and Answer
10:00 Liver
  1. Stem Cells: "Hepatic Stem Cells and the Liver's Maturational Lineages: Relevance to Liver Biology, Pathology and Clinical Programs in Liver Cell Therapies" [Abstract] - Lola M. Reid, University of North Carolina at Chapel Hill
  2. Tissue Engineering: "Creation and Function of 3D Microscale Models of Liver" [Abstract] - Linda Griffith, Ph.D., Professor of Biological and Mechanical Engineering and Director, MIT Biotechnology Process Engineering Center
  3. Translation: "3D Perfusion Bioreactor Technologies for Hepatic Stem Cell Maintenance, Differentiation and Expansion" [Abstract] - Jörg C. Gerlach M.D., Ph.D., Professor of Surgery, School of Medicine, Dept. of Surgery and Professor of Bioengineering, School of Engineering, University of Pittsburgh and McGowan Institute for Regenerative Medicine
10:45 Discussion/Question and Answer
11:00 Skin
  1. Stem Cells: "From Bench to Bedside: a Bumpy Road" [Abstract][Presentation] - Professor Yann Barrandon, M.D., Ph.D., Joint Chair, Ecole Polytechnique Federale de Lausanne (EPFL) - Centre Hospitalier Universitaire Vaudois (CHUV)
  2. Tissue Engineering: "Skin Tissue Engineering: Was it Really So Simple a Challenge...?" [Abstract] - Franiçois Auger, M.D., FRCP(C), Director / LOEX, Full Professor of Surgery, Laval University, Quebec, Canada
  3. Translation: "Opportunities and Obstacles with Engineered Human Skin" [Abstract] - Steven Boyce, Ph.D., Professor, Department of Surgery, University of Cincinnati and Shriners Burns Hospital
11:45 Discussion/Question and Answer
12:00 Lunch


(Chair: Fred Heineken)


1:00 "EU Support for Stem Cell and Tissue Engineering Research" [Presentation] - Charles Kessler, European Commission, Research Directorate-General


1:15 "State of Ohio Third Frontier Project - Perspectives from a Center Awardee"  - Elizabeth Sump, Executive Director, Clinical Tissue Engineering Center
1:30 Missouri: "Stem Cell Research: Science Meets Politics" - Donn Rubin, Executive Director, Coalition for Plant and Life Sciences
1:45 "Maryland's Funding of Stem Cell Research: A Balanced Approach Supporting Scientists, Patients and Biotechs"  - Linda Powers, Chair, Maryland Stem Cell Research Commission (given by Phillip A. Singerman, Ph.D.)


2:00 National Institutes of Health: "Current Activities and Support for Tissue Engineering and Regenerative Medicine at the NIH" [Abstract] - Stephen I. Katz, M.D., Ph.D., Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
2:15 White House Office of Science and Technology Policy: "Coordinating Federal Biotechnology Activities" [Abstract] - Irma E. Arispe, Ph.D., OSTP
2:30 US Food and Drug Administration: "Stem Cell Research for Regenerative Medicine and Tissue Engineering:  FDA Regulatory Issues" - Celia M.Witten, Ph.D., M.D., Director, Office of Cellular, Tissue, and Gene Therapies,  FDA
2:45 Centers for Medicare & Medicaid Services: "Clinical Innovation and New Technology: The Rocky Road to the Bedside in the Medicare Program" [Abstract] - James S. Bowman, Medical Officer, Chronic Care Policy Group, CMS
3:00 Discussion:  Question and Answer
3:15 Summation (Reporter) [Presentation Outline] - Robert M. Nerem, Director, Georgia Tech/Emory Center for the Engineering of Living Tissues (GTEC)
3:45 Discussion/Question and Answer
4:00 "Time for a Change in How the Tissue Engineering Industry Does Business" [Abstract] - Michael J. Lysaght, Director, Center for Biomedical Engineering, Brown University   
4:15 Discussion:  Question and Answer
4:30 Adjourn

Workshop Facilitation by WTEC, Inc.

WTEC, Inc. Workshop Project Manager

Stephen Gould
WTEC, Inc.
4800 Roland Avenue
Suite 201
Baltimore, MD 21210

This material is based upon work supported by the National Science Foundation under Grant No. 0647040.