Membranes for Biological Separations

Supported polymeric membranes can be used to remove low molecular weight organics from aqueous solution (Ho et al. 1996). They work by filling the pores of microfiltration or ultrafiltration membranes with functional, polymeric, or oligomeric liquids that have an affinity for the compound of interest. These ideas can be extended to microemulsions and used for separations of large biological molecules. For example, non-ionic microemulsions (i.e., oil-water systems) have been used for hemoglobin extraction. These results augur well for the separation of other biological materials (Qutubuddin et al. 1994). Molecular imprinting can also be used to produce high surface area adsorbents that are enantioselective for amino acids and other biological molecules (Vidyasankar et al. 1997).

Bacterial Cell Surface Layers as Patterning Elements

Crystalline bacterial cell surface layers (S-layers) are composed of repeating protein units. These layers self-assemble and have a high binding capacity. They have been explored as patterning elements for molecular nanotechnology. For example, they have been used to pattern cadmium sulfide superlattices (Shenton et al. 1997).

Published: September 1999; WTEC Hyper-Librarian