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WTEC Biosensing Study

U.S. R&D Overview Workshop Proceedings

Sponsors: NSF, NIH, USDA, NASA, and ARO

The National Science Foundation, the National Institutes of Health, and other agencies of the U.S. Government have asked the World Technology Evaluation Center, Inc. to perform an assessment of status and trends in biosensing research and development around the world in comparison to that in the United States. The purpose of this study is to assess the U.S. biosensing R&D effort in comparison to activities abroad, provide the scientific/engineering community with a critical view of the field and identify the most promising areas for future research and industrial development, stimulate the development of an interdisciplinary and international community of biosensing researchers, and identify opportunities for international collaboration in the field. WTEC has recruited a panel of U.S. experts in the various related fields to perform this assessment. The panel is charged with analyzing and comparing research in the United States with that being pursued abroad. This panel visited relevant R&D facilities in Japan and Western Europe during the winter and spring of 2003. Prior to these visits the panel first needed to develop an understanding of the state-of-the art in these technologies in the United States.

Towards this end, WTEC invited leading U.S. biosensing researchers to a workshop held at NIH in Bethesda, MD on December 3 and 4, 2002. This volume is a collection of papers presented at the workshop. Paper authors were asked to provide a broad description of all related U.S. work in their respective fields (i.e., not necessarily just the activities in their own laboratories). Authors were chosen to be representative of cutting edge U.S. research in each of the topic areas. This edition also includes overviews of each session prepared by the respective WTEC panelists, as well as some revised contributions.

 Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the United States Government, the authors' parent institutions, or WTEC Inc.

Proceedings

PDF VERSION
  1. Table of Contents & Executive Summary (~47 KB)
  2. SESSION 1: CELL- AND TISSUE-BASED SENSORS (~1.1 MB)
    • Cell- and Tissue-Based Sensors (Sangeeta Bhatia)
    • Living Cells as Sensitive Sensors (Robert S. Burlage).
    • At the Interface Between Biosensors and Living Cells (Christopher S. Chen)
    • Mammalian Cell Sourcing For Use as Sensors (Ron Faris)
  3. SESSION 2: ELECTRO-CHEMICALLY BASED SENSORS (~1.8 MB)
    • Electrochemiluminescence Based Micro-Array Systems for Biochemical Assays and Detection of Biological Agents (James L. Wilbur)
    • Bio/Chemical Sensing using Thin Film Recognition Elements (Richard M. Crooks)
  4. SESSION 3: INFORMATICS AND SYSTEM INTEGRATION (~1.9 MB)
    • Informatics and System Integration (Imant Lauks)
    • Rapid, Reliable, Confident PCR for Bio-Detection (Kurt Petersen)
  5. SESSION 4: DATA ANALYSIS AND MANAGEMENT FOR BIOSENSOR NETWORKS (~21 KB)
    • Data Analysis and Management for Biosensor Networks (David J. Brady)
  6. SESSION 5: OPTICAL BIOSENSING (~1.0 MB)
    • Optical Biosensing (David R. Walt)
    • Chemical and Biological Sensors based on Optical Properties of Materials:
    • luminescence, reflectivity, and plasmon resonant effects (Michael Sailor)
    • Optical Arrays for Biosensing (Frances S. Ligler)
    • Surface Methods for Optical Biosensing (Richard P. Van Duyne)
  7. SESSION 6: MASS SPECTROMETRY AND BIOSENSING RESEARCH (~27 KB)
    • Mass Spectrometry and Biosensing Research (Charles L. Wilkins)
  8. SESSION 7: MICROFABRICATED BIOSENSING DEVICES: MEMS, MICROFLUIDICS, AND MASS SENSORS (~494 KB)
    • Microfabricated Biosensing Devices: MEMS, Microfluidics, and Mass Sensors (Antonio J. Ricco)
    • Ultrasonic Biosensors (Amit Lal)
    • Micro- and Nanofabricated Fluidic Devices for Biosensing (J. Michael Ramsey)
  9. SESSION 8 :U.S. GOVERNMENT AGENCIES' INTERESTS AND ACTIVITIES (~3.0 MB)
    • Aging and Biosensors : National Institute on Aging (Winnie Rossi)
    • Sensors for Biodefense : National Institute of Allergy and Infectious Diseases (Gregory Milman)
    • Unique Capabilities Found in Biology (John Brewer)
    • Biothreat Agent Detection Technology : NRL Chemistry Division (Richard J. Colton)
    • Future Directions in BWA Detection and Diagnosis (Mildred A. Donlon)
    • Biosensing for Agricultural and Food Systems: USDA Perspective (Daniel L. Schmoldt)
    • Biosensing and Biosensing Networks for Information, Decision and Action: Funding
    • Opportunities (Bruce Hamilton and Fred Heineken)
    • Biosensor Research And Activities At The NIH/ National Institute Of Biomedical Imaging And Bioengineering (Christina A. Kelley)
  10. Workshop Contributors
    11. (~11 KB)

Workshop Agenda


December 3, 2002

Time

Presentation

Presenter

9:00 AM

Welcome

Christine Kelley, NIH/NIBIB

9:05 AM

Introduction to the study

Jerry Schultz, Univ. Pittsburgh (WTEC panel chair)

9:10 AM

Opening Remarks

Milan Mrksich, Univ. of Chicago (WTEC panel vice chair)

9:15 AM

 Introduction to bio/cell-based sensors

Sangeeta Bhatia, UCSD (WTEC panel)

9:20 AM

Living cells as sensitive sensors

Robert S. Burlage, Ph.D., Department of Health Sciences, University of Wisconsin-Milwaukee

9:55 AM

Controlling the behavior of cells at interfaces

Chris Chen, Johns Hopkins Univ.

10:30 AM

break

 

10:45 AM

Mammalian cell sourcing for use as sensors

Ron Faris, Brown Univ.

11:20 AM

Introduction to electro-chemically based sensors

Milan Mrksich, Univ. of Chicago (WTEC panel vice chair)

11:25 AM

Electrochemiluminescence Based Micro-Array Systems for Biochemical Assays and Detection of Biological Agents

James L. Wilbur, Ph.D., Meso Scale Diagnostics, LLC.

12:00 PM

lunch (Natcher cafeteria is recommended)

 

1:00 PM

Bio/Chemical Sensing using Thin Film Recognition Elements

Dick Crooks, Texas A&M University

1:35 PM

Introduction to informatics and system integration

Imants Lauks, Epocal (WTEC panel)

2:10 PM

break

 

2:25 PM

Rapid, Reliable, Confident PCR for Bio-Detection

Kurt Petersen, Cepheid

3:10 PM

Sensors/systems fusion overview

David Brady, Duke Univ. (WTEC panel)

3:50 PM

Network integration

TBD

4:25 PM

Introduction to optical methods

David Walt, Tufts University (WTEC panel)

4:30 PM

Chemical and Biological Sensors based on Optical Properties of Materials: luminescence, reflectivity, and plasmon resonant effects

Michael Sailor, UCSD

5:05 PM

Adjourn for the day

 

December 4, 2002

Time

Presentation

Presenter

9:00 AM

Welcome

Geoff Holdridge, WTEC

9:05 AM

Optical Methods (recap)

David Walt, Tufts University (WTEC panel)

9:10 AM

Optical Arrays for Biosensing

Frances S. Ligler, Center for Bio/Molecular Science & Engineering Naval Research Laboratory

9:45 AM

Surface Methods for Optical Biosensing

Richard Van Duyne, Northwestern Univ.

10:20 AM

break

 

10:40 AM

Mass. Spectrometric Methods.

Charles Wilkins, Univ. of Arkansas (WTEC panel)

11:15 AM

Introduction to mass sensors, MEMS, and microfluidics

Tony Ricco, Aclara (WTEC panel)

11:20 AM

MEMS for biosensing applications

Michael Roukes, Caltech

11:55 AM

Lunch (Natcher cafeteria is available)

 

12:55 PM

Mass-sensitive devices for biosensing applications

Amit Lal, Cornell Univ.

1:30 PM

Micro- and Nanofabricated Fluidic Devices for Biosensing

J. Michael Ramsey, Oak Ridge National Lab.

2:05 PM

Review of U.S. Government Agencies’ Interests and Activities (introductions by Geoff Holdridge, WTEC)

2:05 PM

DOE

Dean Cole (BES), NNSA representative (invited)

2:20 PM

NIH/NIBIB

Christine Kelley

2:30 PM

NIH/NIA

Winnie Rossi

2:40 PM

NIH/NIAID

Gregory Milman

2:50 PM

Air Force

John Brewer

3:05 PM

NRL

Richard Colton

3:20 PM

DARPA

Millie Donlon

3:35 PM

USDA

Dan Schmoldt

3:50 PM

NSF

Fred Heineken, Bruce Hamilton

4:05 PM

NIST

John J. Kasianowicz

4:20 PM

Other invited agencies (NASA, ARO, EPA, CDC, etc.)

TBD

4:45 PM

Discussion

 

5:00 PM

Conclude